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Significance of non-lymphoid ('accessory') cells in malignant lymphomas and pseudolymphomas of the skin.
- Source :
- British Journal of Dermatology; Dec1985, Vol. 113 Issue 6, p677-685, 9p
- Publication Year :
- 1985
-
Abstract
- We investigated the co-distribution of lymphocyte subpopulations and non-lymphoid ‘accessory’ cells in 35 cases of cutaneous lymphoproliferative diseases (T-cell lymphoma, 10 cases; B-cell lymphoma, 17 cases; pseudolymphoma, 8 cases) using immunohistochemical methods. T-zone histiocytes and particularly Langerhans cells were abundant in all cutaneous T-cell lymphomas, but were also found in B-cell lymphomas. T-zone histiocytes were associated with T-lymphocytes, especially T-helper cells., but not with T-suppressor cells. Dendritic rcticulum cells were essentially confined to well differentiated germinal centres. Macrophages occurred in both lymphomas and pseudolymphomas without definite relationship with either B- or T-cells. In malignant lymphomas of high grade malignancy, macrophages represented the only non-lymphoid cell type. Our results indicate that malignant lymphoid cells, like normal lymphocytes, require definite micro-environments which are, at least in part, maintained by certain non-lymphoid cells. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00070963
- Volume :
- 113
- Issue :
- 6
- Database :
- Complementary Index
- Journal :
- British Journal of Dermatology
- Publication Type :
- Academic Journal
- Accession number :
- 15239920
- Full Text :
- https://doi.org/10.1111/j.1365-2133.1985.tb02403.x