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Correlation between BNT162b2 mRNA Covid-19 vaccine-associated hypermetabolic lymphadenopathy and humoral immunity in patients with hematologic malignancy.
- Source :
- European Journal of Nuclear Medicine & Molecular Imaging; Oct2021, Vol. 48 Issue 11, p3540-3549, 10p, 1 Diagram, 4 Charts, 2 Graphs
- Publication Year :
- 2021
-
Abstract
- Purpose: Vaccine-associated hypermetabolic lymphadenopathy (VAHL) is frequently observed on [<superscript>18</superscript>F]FDG PET-CT following BNT162b2 administration. Recent data suggest a prominent B cell germinal-center (GC) response elicited by mRNA vaccines in draining lymph nodes. Thus, in this study we aimed to explore the correlation between VAHL and humoral immunity as reflected by post-vaccination serologic testing and by comparing the incidence of VAHL between lymphoma patients treated recently with B cell depleting therapy and those that were not. Methods: A total of 137 patients with hematologic malignancy that had post-vaccination [<superscript>18</superscript>F]FDG PET-CT were included (All-PET group), 86 received both vaccine doses before imaging (PET-2 group). Their VAHL status and grade on imaging were recorded. Among 102 lymphoma patients, 34 (33.3%) were treated during the year prior vaccination with anti-CD20 antibody containing therapy. A subgroup of 54 patients also underwent serologic testing 2–3 weeks after the booster dose, and their anti-spike titers were recorded and graded as well. Results: The overall incidence of VAHL in patients with hematologic malignancy was 31.4%. The 34 lymphoma patients treated during the year prior vaccination with anti-CD20 antibody containing therapy had significantly lower rates of VAHL comparted with all other lymphoma patients (8.8 versus 41.2% in all-PET patients, Pv < 0.01). VAHL rates were 10% in patients with negative serology, 31.3% in patients with low anti-spike titers, and 72.2% in patients with high anti-spike titers. The positive predictive values of VAHL were 90 and 93.3% in all-PET and PET-2 patients, respectively. A positive statistically significant correlation was found between VAHL and serology ranks in All-PET patients (r<subscript>s</subscript> = 0.530, Pv < 0.001), and stronger correlation was found in PET-2 patients (r<subscript>s</subscript> = 0.642, Pv < 0.001). Conclusion: VAHL on [<superscript>18</superscript>F]FDG PET-CT of patients with hematologic malignancy may reflect GC B cell proliferation and an effective humoral response elicited by BNT162b2 vaccine. [ABSTRACT FROM AUTHOR]
- Subjects :
- HUMORAL immunity
COVID-19
HEMATOLOGIC malignancies
COVID-19 vaccines
MESSENGER RNA
Subjects
Details
- Language :
- English
- ISSN :
- 16197070
- Volume :
- 48
- Issue :
- 11
- Database :
- Complementary Index
- Journal :
- European Journal of Nuclear Medicine & Molecular Imaging
- Publication Type :
- Academic Journal
- Accession number :
- 152447046
- Full Text :
- https://doi.org/10.1007/s00259-021-05389-x