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HIV/AIDS-Pneumonia Coinfection Model with Treatment at Each Infection Stage: Mathematical Analysis and Numerical Simulation.
- Source :
- Journal of Applied Mathematics; 9/17/2021, p1-21, 21p
- Publication Year :
- 2021
-
Abstract
- In the paper, we have considered a nonlinear compartmental mathematical model that assesses the effect of treatment on the dynamics of HIV/AIDS and pneumonia coinfection in a human population at different infection stages. Our model revealed that the disease-free equilibrium points of the HIV/AIDS and pneumonia submodels are both locally and globally asymptotically stable whenever the associated basic reproduction numbers ( R H and R P ) are less than unity. Both the submodel endemic equilibrium points are locally and globally asymptotically stable whenever the associated basic reproduction numbers ( R P and R H ) are greater than unity. The full HIV/AIDS-pneumonia coinfection model has both locally and globally asymptotically stable disease-free equilibrium points whenever the basic reproduction number of the coinfection model R H P is less than unity. Using standard values of parameters collected from different kinds of literature, we found that the numerical values of the basic reproduction numbers of the HIV/AIDS-only submodel and pneumonia-only submodel are 17 and 7, respectively, and the basic reproduction number of the HIV/AIDS-pneumonia coinfection model is max 7 , 17 = 17. Applying sensitive analysis, we identified the most influential parameters to change the behavior of the solution of the considered coinfection dynamical system are the HIV/AIDS and pneumonia transmission rates β 1 and β 2 , respectively. The coinfection model was numerically simulated to investigate the stability of the coinfection endemic equilibrium point, the impacts of transmission rates, and treatment strategies for HIV/AIDS-only, pneumonia-only, and HIV/AIDS-pneumonia coinfected individuals. Finally, we observed that numerical simulations indicate that treatment against infection at every stage lowers the rate of infection or disease prevalence. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 1110757X
- Database :
- Complementary Index
- Journal :
- Journal of Applied Mathematics
- Publication Type :
- Academic Journal
- Accession number :
- 152512284
- Full Text :
- https://doi.org/10.1155/2021/5444605