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Enantioselective Synthesis of Atropisomeric Biaryls by Pd‐Catalyzed Asymmetric Buchwald–Hartwig Amination.
- Source :
- Angewandte Chemie; 9/27/2021, Vol. 133 Issue 40, p21886-21890, 5p
- Publication Year :
- 2021
-
Abstract
- N−C Biaryl atropisomers are prevalent in natural products and bioactive drug molecules. However, the enantioselective synthesis of such molecules has not developed significantly. Particularly, the enantioselective synthesis of N−C biaryl atropisomers by stereoselective metal‐catalyzed aryl amination remains unprecedented. Herein, a Pd‐catalyzed cross‐coupling strategy is presented for the synthesis of N−C axially chiral biaryl molecules. A broad spectrum of N−C axially chiral compounds was obtained with excellent enantioselectivities (up to 99 % ee) and good yields (up to 98 %). The practicality of this reaction was validated in the synthesis of useful biological molecules. [ABSTRACT FROM AUTHOR]
- Subjects :
- AMINATION
BIOMOLECULES
BIOSYNTHESIS
ATROPISOMERS
NATURAL products
MOLECULES
Subjects
Details
- Language :
- English
- ISSN :
- 00448249
- Volume :
- 133
- Issue :
- 40
- Database :
- Complementary Index
- Journal :
- Angewandte Chemie
- Publication Type :
- Academic Journal
- Accession number :
- 152539972
- Full Text :
- https://doi.org/10.1002/ange.202108747