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Ring-like late gadolinium enhancement for predicting ventricular tachyarrhythmias in non-ischaemic dilated cardiomyopathy.
- Source :
- European Heart Journal - Cardiovascular Imaging; Oct2021, Vol. 22 Issue 10, p1130-1138, 9p
- Publication Year :
- 2021
-
Abstract
- Aims Myocardial fibrosis is associated with clinical ventricular tachyarrhythmia (VTA) events in patients with non-ischaemic dilated cardiomyopathy (DCM). Subepicardial or mid-wall ring-like late gadolinium enhancement (LGE) has received increasing attention in recent years. The aim of this study was to investigate the relationship between ring-like LGE and VTAs in DCM. Methods and results Patients diagnosed with non-ischaemic DCM who underwent cardiac magnetic resonance with LGE imaging at baseline were investigated. The composite outcome was the occurrence of VTAs defined as sustained ventricular tachycardia, ventricular fibrillation/flutter, aborted sudden cardiac death (SCD), SCD, and appropriate implantable cardioverter-defibrillator intervention. The final cohort comprised 157 patients, including 36 (22.9%) in no LGE group, 48 (30.6%) in focal LGE group, 40 (25.5%) in multi-focal LGE group, and 33 (21%) in ring-like LGE group. Ring-like LGE group patients were younger compared to focal and multi-focal LGE group (P < 0.001) with higher left ventricular ejection fraction (33.0% vs. 24.4% vs. 22.1%, P < 0.001). After a median of 13 ± 7 months follow-up, compared to patients with no LGE, the hazard ratios (HRs) with 95% confidence intervals (CIs) for VTAs were 2.90 (0.56–15.06), 5.55 (1.21–25.44), and 11.75 (2.66–51.92) for patients with focal LGE, multi-focal LGE, and ring-like LGE, respectively. After multivariable adjustment, ring-like LGE group remained associated with increased risk of VTAs (adjusted HR 10.00, 95% CI 1.54–64.98; P = 0.016) independent of the global LGE burden Conclusion The ring-like pattern of LGE is independently associated with an increased risk of VTAs in patients with non-ischaemic DCM. [ABSTRACT FROM AUTHOR]
- Subjects :
- RISK assessment
DIAGNOSTIC imaging
VENTRICULAR ejection fraction
CHEMICAL elements
DILATED cardiomyopathy
MAGNETIC resonance imaging
RETROSPECTIVE studies
VENTRICULAR fibrillation
DESCRIPTIVE statistics
AGE distribution
MULTIVARIATE analysis
VENTRICULAR tachycardia
LONGITUDINAL method
IMPLANTABLE cardioverter-defibrillators
CARDIAC arrest
COMPARATIVE studies
CONFIDENCE intervals
DISEASE risk factors
DISEASE complications
Subjects
Details
- Language :
- English
- ISSN :
- 20472404
- Volume :
- 22
- Issue :
- 10
- Database :
- Complementary Index
- Journal :
- European Heart Journal - Cardiovascular Imaging
- Publication Type :
- Academic Journal
- Accession number :
- 152607973
- Full Text :
- https://doi.org/10.1093/ehjci/jeab117