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Evaluation of pro-angiogenic properties of an inorganic silica gel fibre fleece.
- Source :
- Journal of Wound Care; Sep2021, Vol. 30 Issue 9, p729-736, 8p
- Publication Year :
- 2021
-
Abstract
- Hard-to-heal wounds represent an increasing health and economic burden on society. At present, therapy options for hard-to-heal wounds are often unsatisfactory, and the development of more effective wound treatments is urgently needed. We have shown that orthosilicic acid-releasing silica fibre fleece (SIFIB), via its pronounced anti-inflammatory properties, exhibited a significantly enhanced effect on wound closure kinetics in a porcine wound model in vivo. In this present study, we have examined in vitro the impact of the pro-angiogenic potential of SIFIB. Using an in vitro angiogenesis assay we describe for the first time how an inorganic biodegradable silica-based material significantly improved endothelial microvessel-like structure formation. We further demonstrate that the molecular mechanism of this pro-angiogenic activity of SIFIB is based on a significantly increased and tumour necrosis factor (TNF)α-dependent VEGF protein expression. In conclusion, due to its positive effects on angiogenesis, our results further indicate that decomposition products of silica-based biodegradable inorganic materials might represent very relevant therapeutic components of modern wound dressings for the treatment of hard-to-heal wounds. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 09690700
- Volume :
- 30
- Issue :
- 9
- Database :
- Complementary Index
- Journal :
- Journal of Wound Care
- Publication Type :
- Academic Journal
- Accession number :
- 152611061
- Full Text :
- https://doi.org/10.12968/jowc.2021.30.9.729