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Attenuation of PITPNM1 Signaling Cascade Can Inhibit Breast Cancer Progression.

Authors :
Liu, Zihao
Shi, Yu
Lin, Qun
Yang, Wenqian
Luo, Qing
Cen, Yinghuan
Li, Juanmei
Fang, Xiaolin
Jiang, Wen G.
Gong, Chang
Source :
Biomolecules (2218-273X); Sep2021, Vol. 11 Issue 9, p1265-1265, 1p
Publication Year :
2021

Abstract

Phosphatidylinositol transfer protein membrane-associated 1 (PITPNM1) contains a highly conserved phosphatidylinositol transfer domain which is involved in phosphoinositide trafficking and signaling transduction under physiological conditions. However, the functional role of PITPNM1 in cancer progression remains unknown. Here, by integrating datasets of The Cancer Genome Atlas (TCGA) and Molecular Taxonomy of Breast Cancer (METABRIC), we found that the expression of PITPNM1 is much higher in breast cancer tissues than in normal breast tissues, and a high expression of PITPNM1 predicts a poor prognosis for breast cancer patients. Through gene set variation analysis (GSEA) and gene ontology (GO) analysis, we found PITPNM1 is mainly associated with carcinogenesis and cell-to-cell signaling ontology. Silencing of PITPNM1, in vitro, significantly abrogates proliferation and colony formation of breast cancer cells. Collectively, PITPNM1 is an important prognostic indicator and a potential therapeutic target for breast cancer. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
2218273X
Volume :
11
Issue :
9
Database :
Complementary Index
Journal :
Biomolecules (2218-273X)
Publication Type :
Academic Journal
Accession number :
152658030
Full Text :
https://doi.org/10.3390/biom11091265