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Evaluation of VEGF-A in platelet and microRNA-126 in serum after coronary artery bypass grafting.
- Source :
- Heart & Vessels; Nov2021, Vol. 36 Issue 11, p1635-1645, 11p
- Publication Year :
- 2021
-
Abstract
- Platelet functions are thought to contribute to clinical outcomes after heart surgery. This study was conducted to assess the pivotal roles of vascular endothelial growth factor-A (VEGF-A) and microRNA-126 (miR-126) during coronary artery bypass grafting (CABG). Whole blood was collected for platelet isolation from 67 patients who underwent CABG surgery between July 2013 and March 2014. VEGF-A and miR-126 levels in serum, plasma, and platelets were measured at various time points and compared with clinical characteristics. The platelet count was decreased at 3 days after CABG. This dynamic change in platelet count was larger after conventional coronary artery bypass (CCAB) than off-pump coronary artery bypass (OPCAB). VEGF-A in the same number of platelets (IP-VEGF-A) was increased at 3 days after CABG, followed by an increase of VEGF-A in serum (S-VEGF-A) at 7 days after surgery. The miR-126-3p level in serum (S-miR-126-3p) increased rapidly after CABG and then decreased below preoperative levels. The IP-VEGF-A level on day 7 after CABG in patients with peripheral artery disease (PAD), who suffered from endothelial dysfunction, was higher compared with patients without PAD. Conversely, S-miR-126-3p on day 7 after surgery was lower in patients with PAD than in patients without PAD. Low levels of S-miR-126-3p due to endothelial dysfunction may lead to high IP-VEGF-A, which is closely related to complications after CABG. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 09108327
- Volume :
- 36
- Issue :
- 11
- Database :
- Complementary Index
- Journal :
- Heart & Vessels
- Publication Type :
- Academic Journal
- Accession number :
- 152710391
- Full Text :
- https://doi.org/10.1007/s00380-021-01855-6