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Watch and wait in Waldenström macroglobulinaemia: looking for who to watch carefully and who can wait without worrying. Is it that simple?
- Source :
- British Journal of Haematology; Oct2021, Vol. 195 Issue 2, p155-157, 3p
- Publication Year :
- 2021
-
Abstract
- Observation is recommended for patients without immunoglobulin M (IgM)-related complications and/or symptoms related to bone marrow or extramedullary lymphoplasmacytic involvement.2 Asymptomatic IgM monoclonal gammopathy encompasses two clinicopathological entities with a distinct risk of progression to symptomatic WM: IgM monoclonal gammopathy of undetermined significance (IgM MGUS) and smouldering WM (SWM). In their paper, Zanwar I et al i .11 focussed on patients with SWM with the aim of identifying risk factors for early progression to symptomatic WM. Interestingly, they were able to identify a subset of patients (30% of patients with the two variables available) with a high risk of progression to symptomatic WM (median TTP 2-4 years). Zanwar I et al i .11 report that patients with SWM represent one-fifth of patients with WM. [Extracted from the article]
- Subjects :
- MONOCLONAL gammopathies
WALDENSTROM'S macroglobulinemia
OVERALL survival
Subjects
Details
- Language :
- English
- ISSN :
- 00071048
- Volume :
- 195
- Issue :
- 2
- Database :
- Complementary Index
- Journal :
- British Journal of Haematology
- Publication Type :
- Academic Journal
- Accession number :
- 152925546
- Full Text :
- https://doi.org/10.1111/bjh.17699