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Comparison of survival outcomes with or without Para-aortic lymphadenectomy in surgical patients with stage IB1-IIA2 cervical cancer in China from 2004 to 2016.
- Source :
- BMC Cancer; 10/9/2021, Vol. 21 Issue 1, p1-11, 11p
- Publication Year :
- 2021
-
Abstract
- <bold>Background: </bold>Current opinions on whether surgical patients with cervical cancer should undergo para-aortic lymphadenectomy at the same time are inconsistent. The present study examined differences in survival outcomes with or without para-aortic lymphadenectomy in surgical patients with stage IB1-IIA2 cervical cancer.<bold>Methods: </bold>We retrospectively compared the survival outcomes of 8802 stage IB1-IIA2 cervical cancer patients (FIGO 2009) who underwent abdominal radical hysterectomy + pelvic lymphadenectomy (nā=ā8445) or abdominal radical hysterectomy + pelvic lymphadenectomy + para-aortic lymphadenectomy (nā=ā357) from 37 hospitals in mainland China.<bold>Results: </bold>Among the 8802 patients with stage IB1-IIA2 cervical cancer, 1618 (18.38%) patients had postoperative pelvic lymph node metastases, and 37 (10.36%) patients had para-aortic lymph node metastasis. When pelvic lymph nodes had metastases, the para-aortic lymph node simultaneous metastasis rate was 30.00% (36/120). The risk of isolated para-aortic lymph node metastasis was 0.42% (1/237). There were no significant differences in the survival outcomes between the para-aortic lymph node unresected and resected groups. No differences in the survival outcomes were found before or after matching between the two groups regardless of pelvic lymph node negativity/positivity.<bold>Conclusion: </bold>Para-aortic lymphadenectomy did not improve 5-year survival outcomes in surgical patients with stage IB1-IIA2 cervical cancer. Therefore, when pelvic lymph node metastasis is negative, the risk of isolated para-aortic lymph node metastasis is very low, and para-aortic lymphadenectomy is not recommended. When pelvic lymph node metastasis is positive, para-aortic lymphadenectomy should be carefully selected because of the high risk of this procedure. [ABSTRACT FROM AUTHOR]
- Subjects :
- LYMPHADENECTOMY
SURVIVAL rate
CERVICAL cancer
LYMPHATIC metastasis
HYSTERECTOMY
TREATMENT effectiveness
RESEARCH
RESEARCH methodology
METASTASIS
CASE-control method
RETROSPECTIVE studies
MEDICAL cooperation
EVALUATION research
COMPARATIVE studies
SURVIVAL analysis (Biometry)
CERVIX uteri tumors
SURGICAL excision
LYMPH node surgery
PELVIS
LONGITUDINAL method
Subjects
Details
- Language :
- English
- ISSN :
- 14712407
- Volume :
- 21
- Issue :
- 1
- Database :
- Complementary Index
- Journal :
- BMC Cancer
- Publication Type :
- Academic Journal
- Accession number :
- 152926979
- Full Text :
- https://doi.org/10.1186/s12885-021-08797-2