Efficient Synthesis of α‐Ketothioamides From α‐Nitroketones, Amines or DMF and Elemental Sulfur Under Oxidant‐Free Conditions.

We have developed a practical, general protocol for denitration of readily available α‐nitroketones with sulfur and amines to access a broad range of α‐ketothioamides under mild conditions. Such a reaction proceeds under metal‐, oxidant‐, and catalyst‐free conditions to provide synthetically useful α‐ketothioamides. Furthermore, the mild reaction conditions tolerate a wide range of substrates especially for the synthesis of aliphatic α‐ketothioamides which are rarely reported. [ABSTRACT FROM AUTHOR]