Gold Glyconanoparticles Based on Aldoses 6-Mercaptohexanoyl Hydrazones and Their Anti-Influenza Activity.

A method for the synthesis of mixed-ligand gold glyconanoparticles with average particle size of 20–25 nm at widely variable ratio of the initial glycoligands on the basis of aldoses 6-mercaptohexanoyl hydrazones—condensation products of a series of natural aldoses (N-acetylamino-D-glucose, D-mannose, D-galactose, and L-fucose) with 6-mercaptohexanoic acid hydrazide—has been developed. It has been shown that the obtained gold glyconanoparticles exhibit low toxicity and are active against influenza A/Puerto Rico/8/34 (H1N1) virus at concentrations of 3 and 6 μg/mL. [ABSTRACT FROM AUTHOR]