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Cochleate Formulation Enhances the Stability of Lansoprazole in Acidic Condition.
- Source :
- Bulletin of the Korean Chemical Society; Oct2021, Vol. 42 Issue 10, p1281-1284, 4p
- Publication Year :
- 2021
-
Abstract
- Lansoprazole (LSP)āloaded cochleates were developed using dimyristoyl phosphatidylcholine (DMPC) and cholesterol in the presence or absence of dicetyl phosphate (DCP). Cochleates containing DCP exhibited unique cylindrical morphologies, resulting in improved LSP loading and enhanced stability in an acidic environment. Thus, we suggest that the use of negatively charged components, such as DCP, is needed to formulate cochleates using a neutrally charged lipid such as DMPC. [ABSTRACT FROM AUTHOR]
- Subjects :
- LANSOPRAZOLE
LECITHIN
CHOLESTEROL
PHOSPHATES
Subjects
Details
- Language :
- English
- ISSN :
- 02532964
- Volume :
- 42
- Issue :
- 10
- Database :
- Complementary Index
- Journal :
- Bulletin of the Korean Chemical Society
- Publication Type :
- Academic Journal
- Accession number :
- 153245478
- Full Text :
- https://doi.org/10.1002/bkcs.12360