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Dietary ω-3 polyunsaturated fatty acids are protective for myopia.
- Source :
- Proceedings of the National Academy of Sciences of the United States of America; 10/26/2021, Vol. 118 Issue 43, p1-12, 12p
- Publication Year :
- 2021
-
Abstract
- Myopia is a leading cause of visual impairment and blindness worldwide. However, a safe and accessible approach for myopia control and prevention is currently unavailable. Here, we investigated the therapeutic effect of dietary supplements of omega-3 polyunsaturated fatty acids (ω-3 PUFAs) on myopia progression in animal models and on decreases in choroidal blood perfusion (ChBP) caused by near work, a risk factor for myopia in young adults. We demonstrated that daily gavage of ω-3 PUFAs (300 mg docosahexaenoic acid [DHA] plus 60 mg eicosapentaenoic acid [EPA]) significantly attenuated the development of form deprivation myopia in guinea pigs and mice, as well as of lens-induced myopia in guinea pigs. Peribulbar injections of DHA also inhibited myopia progression in form-deprived guinea pigs. The suppression of myopia in guinea pigs was accompanied by inhibition of the "ChBP reduction-scleral hypoxia cascade." Additionally, treatment with DHA or EPA antagonized hypoxia-induced myofibroblast transdifferentiation in cultured human scleral fibroblasts. In human subjects, oral administration of ω-3 PUFAs partially alleviated the near-work-induced decreases in ChBP. Therefore, evidence from these animal and human studies suggests ω-3 PUFAs are potential and readily available candidates for myopia control. [ABSTRACT FROM AUTHOR]
- Subjects :
- UNSATURATED fatty acids
MYOPIA
OMEGA-3 fatty acids
EICOSAPENTAENOIC acid
GUINEA pigs
Subjects
Details
- Language :
- English
- ISSN :
- 00278424
- Volume :
- 118
- Issue :
- 43
- Database :
- Complementary Index
- Journal :
- Proceedings of the National Academy of Sciences of the United States of America
- Publication Type :
- Academic Journal
- Accession number :
- 153307493
- Full Text :
- https://doi.org/10.1073/pnas.2104689118