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Strategy for the multi-component characterization and quality evaluation of volatile organic components in Kaixin San by correlating the analysis by headspace gas chromatography/ion mobility spectrometry and headspace gas chromatography/ mass spectrometry.
- Source :
- Rapid Communications in Mass Spectrometry: RCM; 11/15/2021, Vol. 35 Issue 21, p1-11, 11p
- Publication Year :
- 2021
-
Abstract
- Rationale: Kaixin San (KXS) is a prescription traditional Chinese medicine (TCM) with the effects of "tonifying the kidney and brain" and "improving memory". The volatile organic compounds (VOCs) in KXS could effectively improve senile dementia and depression, but only few studies have focused on the overall characterization of VOCs in KXS and the quantitative study of the main active components. Methods: We have developed a strategy to correlate the results from headspace gas chromatography/ion mobility spectrometry (HS-GC/IMS) and headspace gas chromatography/mass spectrometry (HS-GC/MS) for the comprehensive characterization of VOCs in KXS and the quantitative analysis of the main pharmacodynamic substances. Results: A totsal of 68 low molecular weight VOCs were identified in KXS by HSGC/IMS at room temperature and atmospheric pressure; 117 VOCs were identified and 10 components (isocalamenediol, α-asarone, β-asarone, methyl eugenol, isoeugenol methyl ether, camphor, anethol, 2,4-di-tert-butylphol, linalool, asarylaldehyde) as the quality markers of KXS based on HS-GC/MS. Conclusions: This results from this study provide a foundation for quality control, pharmacodynamic mechanism research and further development of KXS, and provides more convincing data supporting the VOCs of other natural products. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 09514198
- Volume :
- 35
- Issue :
- 21
- Database :
- Complementary Index
- Journal :
- Rapid Communications in Mass Spectrometry: RCM
- Publication Type :
- Academic Journal
- Accession number :
- 153354276
- Full Text :
- https://doi.org/10.1002/rcm.9174