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A paper-based sensor for rapid and ultrasensitive detection of ibuprofen in water and herbal tea.
- Source :
- Analyst; 11/21/2021, Vol. 146 Issue 22, p6874-6882, 9p
- Publication Year :
- 2021
-
Abstract
- As the use of non-steroidal anti-inflammatory drugs (NSAIDS) increases, their side effects have also attracted attention. Ibuprofen is one of the most widely-used NSAIDs. In this study, we screened the highly-sensitive and specific antibody 6E10, with an IC<subscript>50</subscript> of 1.92 ng mL<superscript>−1</superscript>, and a linear range of 0.53–6.97 ng mL<superscript>−1</superscript>. In this study, we developed a rapid lateral flow immunochromatographic assay (ICA) strip method to detect ibuprofen in water or herbal tea. The cut-off limit of the strip is 10 ng mL<superscript>−1</superscript> in water, and concentrations as low as 1 ng mL<superscript>−1</superscript> can be detected in herbal tea samples, with the results obtained by the naked eye within 6 min. All the data were confirmed by high performance liquid chromatography-quadrupole time of flight-mass spectrometry (HPLC-QTOF-MS). This lateral-flow ICA strip is thus a rapid tool for on-site detection and screening of ibuprofen in water and herbal tea. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00032654
- Volume :
- 146
- Issue :
- 22
- Database :
- Complementary Index
- Journal :
- Analyst
- Publication Type :
- Academic Journal
- Accession number :
- 153460963
- Full Text :
- https://doi.org/10.1039/d1an01533h