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Alteration in Cngb1 Expression upon Maternal Immune Activation in a Mouse Model and Its Possible Association with Schizophrenia Susceptibility.
- Source :
- Clinical Psychopharmacology & Neuroscience; Nov2021, Vol. 19 Issue 4, p618-627, 10p
- Publication Year :
- 2021
-
Abstract
- Objective: The cyclic nucleotide-gated channel (Cng) regulates synaptic efficacy in brain neurons by modulating Ca<superscript>2+</superscript> levels in response to changes in cyclic nucleotide concentrations. This study investigated whether the expression of Cng channel, cyclic nucleotide-gated channel subunit beta 1 (Cngb1) exhibited any relationship with the pathophysiology of schizophrenia in an animal model and whether genetic polymorphisms of the human gene were associated with the progression of schizophrenia in a Korean population. Methods: We investigated whether Cngb1 expression was related to psychiatric disorders in a mouse model of schizophrenia induced by maternal immune activation. A case-control study was conducted of 275 schizophrenia patients and 410 controls with single-nucleotide polymorphisms (SNPs) in the 5′-near region of CNGB1. Results: Cngb1 expression was decreased in the prefrontal cortex in the mouse model. Furthermore, the genotype frequency of a SNP (rs3756314) of CNGB1 was associated with the risk of schizophrenia. Conclusion: Our results suggest that CNGB1 might be associated with schizophrenia susceptibility and maternal immune activation. Consequently, it is hypothesized that CNGB1 may be involved in the pathophysiology of schizophrenia. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 17381088
- Volume :
- 19
- Issue :
- 4
- Database :
- Complementary Index
- Journal :
- Clinical Psychopharmacology & Neuroscience
- Publication Type :
- Academic Journal
- Accession number :
- 153568047
- Full Text :
- https://doi.org/10.9758/cpn.2021.19.4.618