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Organocatalytic Enantioselective [8+4] Cycloadditions of Isobenzofulvenes for the Construction of Bicyclo[4.2.1]nonanes.
- Source :
- Chinese Journal of Chemistry; Dec2021, Vol. 39 Issue 12, p3219-3224, 6p
- Publication Year :
- 2021
-
Abstract
- Main observation and conclusion: The [8+4] cycloaddition of indene‐2‐carbaldehydes with indole‐2,3‐quinodimethanes and pyrrolidone‐3,4‐dienes is described, affording indole and pyrrolidone annulated bicyclo[4.2.1]nonanes in a highly peri‐, diastereo‐, and enantioselective fashion in the presence of a secondary amine catalyst. This reaction, which proceeds through catalytically generated isobenzofulvenes, represents the first asymmetric version of high‐order [8+4] cycloaddition. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 1001604X
- Volume :
- 39
- Issue :
- 12
- Database :
- Complementary Index
- Journal :
- Chinese Journal of Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 153578748
- Full Text :
- https://doi.org/10.1002/cjoc.202100250