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Synergistic Copper and Chiral Lewis Base Catalysis for the Asymmetric Synthesis of Pyrrolo[1,2‐a]indoles.
- Source :
- Chinese Journal of Chemistry; Dec2021, Vol. 39 Issue 12, p3292-3296, 5p
- Publication Year :
- 2021
-
Abstract
- Main observation and conclusion: The first asymmetric decarboxylative [3+2]‐cycloaddition of ethynyl indoloxazolidones with carboxylic acids has been developed under synergistic catalysis of copper and chiral Lewis base. This protocol provides a direct and modular approach to biologically important pyrrolo[1,2‐a]indoles bearing two vicinal stereogenic centers with excellent diastereo‐ and enantioselectivities (up to >20 : 1 dr and >99% ee). In addition, the utility of this methodology was demonstrated by scaled‐up reaction and several synthetic transformations of the cycloadduct. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 1001604X
- Volume :
- 39
- Issue :
- 12
- Database :
- Complementary Index
- Journal :
- Chinese Journal of Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 153578767
- Full Text :
- https://doi.org/10.1002/cjoc.202100476