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An isocamphanyl-based fluorescent "turn-on" probe for highly sensitive and selective detection of Ga3+ and application in vivo and in vitro.
- Source :
- Analyst; 12/7/2021, Vol. 146 Issue 23, p7294-7305, 12p
- Publication Year :
- 2021
-
Abstract
- A novel fluorescent probe 2-(4-(diethylamino)-2-hydroxybenzylidene)-N-(2,3,3-trimethylbicyclo[2.2.1]heptan-2-yl)hydrazinecarbothioamide (HT) was prepared in this study by a condensation reaction. HT has been confirmed to possess high specificity toward Ga<superscript>3+</superscript> over other metal ions (including Al<superscript>3+</superscript> and In<superscript>3+</superscript>) via a distinct fluorescence light-up response. Moreover, HT exhibited good detection performances for Ga<superscript>3+</superscript> including high selectivity, excellent anti-interference ability, a wide working pH range, and good reversibility. The association constant and limit of detection (LOD) were calculated to be 5.34 × 10<superscript>3</superscript> M<superscript>−1</superscript> and 1.18 × 10<superscript>−6</superscript> M, respectively. The detection mechanism of HT toward Ga<superscript>3+</superscript> was proposed and confirmed by <superscript>1</superscript>H NMR analysis, HRMS analysis, and DFT calculations. A simple test strip-based portable detecting device and a molecular INHIBIT logic circuit were established for improving its practical applicability. Furthermore, the desirable sensing performance of HT for Ga<superscript>3+</superscript> was successfully reconfirmed in MCF-7 cells and zebrafish. [ABSTRACT FROM AUTHOR]
- Subjects :
- LOGIC circuits
CONDENSATION reactions
BINDING constant
FLUORESCENT probes
METAL ions
Subjects
Details
- Language :
- English
- ISSN :
- 00032654
- Volume :
- 146
- Issue :
- 23
- Database :
- Complementary Index
- Journal :
- Analyst
- Publication Type :
- Academic Journal
- Accession number :
- 153705210
- Full Text :
- https://doi.org/10.1039/d1an01368h