Commentary: Large Acid-Evoked Currents, Mediated by ASIC1a, Accompany Differentiation in Human Dopaminergic Neurons.

They have proposed that ASICs are responsible for the differentiation of LUHMES (Lund Human Mesencephalic) cells, a line of human cells capable of differentiating into dopaminergic-like neurons (Zuberek et al., [26]; Harischandra et al., [5]). Keywords: acid-sensing ion channel; dopamine cell; differentiation; patch-clamp recording; human cell EN acid-sensing ion channel dopamine cell differentiation patch-clamp recording human cell 1 3 3 11/25/21 20211122 NES 211122 Introduction Acid-sensing ion channels (ASICs) are proton-gated Na SP + sp channels widely located in the peripheral and central nervous system (Waldmann et al., [21]; Krishtal, [9]). Differentiation, patch-clamp recording, acid-sensing ion channel, dopamine cell, human cell. [Extracted from the article]