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Ultra-compact micro-photoacoustic tomography for brain imaging in vivo.
- Source :
- Applied Physics Letters; 11/22/2021, Vol. 119 Issue 21, p1-6, 6p
- Publication Year :
- 2021
-
Abstract
- In vivo wide-field brain microscopy has remained a non-trivial challenge in life science research, which would provide indispensable preclinical insight into the whole-brain metabolism and hemodynamic. Here, we developed an ultra-compact micro-photoacoustic tomography (μPAT) system for fast brain imaging equipped with a 10 MHz 256-element full-ring ultrasound transducer array and 100 MS/s/ch multi-channel parallel data acquisition. The system design and calibration are presented in detail, along with the 62 μm in-plane resolution comparable to the level of acoustic-resolution photoacoustic microscopy. The μPAT system provided the ability to noninvasively use high-resolution mapping of the microvascular network of the full-view brain at different depths, cerebral ischemia, and intracerebral foreign-body. Ultra-compact μPAT holds great potential to take the technology out of the lab for preclinical imaging and clinical translation. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00036951
- Volume :
- 119
- Issue :
- 21
- Database :
- Complementary Index
- Journal :
- Applied Physics Letters
- Publication Type :
- Academic Journal
- Accession number :
- 153795191
- Full Text :
- https://doi.org/10.1063/5.0076948