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Critically Ill Coronavirus Disease 2019 Patients Exhibit Hyperactive Cytokine Responses Associated With Effector Exhausted Senescent T Cells in Acute Infection.
- Source :
- Journal of Infectious Diseases; 11/15/2021, Vol. 224 Issue 10, p1672-1683, 12p
- Publication Year :
- 2021
-
Abstract
- <bold>Background: </bold>Coronavirus disease 2019 (COVID-19) can progress to severe pneumonia with respiratory failure and is aggravated by the deregulation of the immune system causing an excessive inflammation including the cytokine storm.<bold>Methods: </bold>In this study, we report that severe acutely infected patients have high levels of both type-1 and type-2 cytokines.<bold>Results: </bold>Our results show abnormal cytokine levels upon T-cell stimulation, in a nonpolarized profile. Furthermore, our findings indicate that this hyperactive cytokine response is associated with a significantly increased frequency of late-differentiated T cells with particular phenotype of effector exhausted/senescent CD28-CD57+ cells. Of note, we demonstrated for the first time an increased frequency of CD3+CD4+CD28-CD57+ T cells with expression of programmed death 1, one of the hallmarks of T-cell exhaustion.<bold>Conclusions: </bold>These findings reveal that COVID-19 is associated with acute immunodeficiency, especially within the CD4+ T-cell compartment, and points to possible mechanisms of loss of clonal repertoire and susceptibility to viral relapse and reinfection events. [ABSTRACT FROM AUTHOR]
- Subjects :
- COVID-19
T cells
CYTOKINES
CRITICALLY ill
CYTOKINE release syndrome
Subjects
Details
- Language :
- English
- ISSN :
- 00221899
- Volume :
- 224
- Issue :
- 10
- Database :
- Complementary Index
- Journal :
- Journal of Infectious Diseases
- Publication Type :
- Academic Journal
- Accession number :
- 153798238
- Full Text :
- https://doi.org/10.1093/infdis/jiab425