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Histopathological and ultrastructural study of carotid atherosclerotic plaques: a study of four cases.
- Source :
- Ultrastructural Pathology; Jul-Sep 2021, Vol. 45 Issue 4/5, p319-334, 16p
- Publication Year :
- 2021
-
Abstract
- To clarify the characteristics and origin of the cellular components in atherosclerosis, carotid atherosclerotic plaques (CAPs) of four patients were studied by light microscopy using hematoxylin-eosin, Congo red and alpha-smooth-muscle actin stains, and by transmission electron microscopy of different regions of CAPs. By light microscopy, CAPs were composed of 1) a fibrous cap; 2) an atherosclerotic core presenting focal fibrosis, neovascularization, hemorrhage, necrosis, chondrification and ossification; and 3) a basal band composed of a hyperplasic pseudo-media and affected tunica media. Ultrastructurally, the CAPs contained a diversity of cells including fibroblasts, myofibroblasts, osteochondrocytes, vascular smooth-muscle cells, foam cells and other myoid cells characterized by varied features of the above mentioned cells. The results indicated that CAPs were derived from a proliferation of multipotential mesenchymal stem cells, leading to the presence of degenerated foam cells and lipid-laden cells. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 01913123
- Volume :
- 45
- Issue :
- 4/5
- Database :
- Complementary Index
- Journal :
- Ultrastructural Pathology
- Publication Type :
- Academic Journal
- Accession number :
- 153815977
- Full Text :
- https://doi.org/10.1080/01913123.2021.1968090