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Salmonella Typhi Shedding and Household Transmission by Children With Blood Culture-Confirmed Typhoid Fever in Vellore, South India.
- Source :
- Journal of Infectious Diseases; 2021 Supplement, Vol. 224, pS593-S600, 8p
- Publication Year :
- 2021
-
Abstract
- <bold>Background: </bold>Children suffer the highest burden of the typhoid fever, with a considerable proportion shedding Salmonella Typhi in stool, potentially resulting in transmission of S Typhi.<bold>Methods: </bold>We enrolled 70 children with blood culture-confirmed typhoid fever (index cases), from 63 households, during community-based fever surveillance in India. The index cases and their household contacts were followed up with stool samples at multiple time points over 3 weeks and 1 week, respectively. S Typhi was detected using quantitative real-time polymerase chain reaction.<bold>Results: </bold>Fifteen of 70 (21.4%) children with culture-confirmed typhoid fever shed S Typhi in stool after onset of fever. Ten of 15 children shed S Typhi for a median of 11.5 (range, 3-61) days from the day of completion of antibiotics. Of 172 household contacts from 56 of the 63 index case households, 12 (7%) contacts in 11 (19.6%) households had S Typhi in stool. Five of the 12 contacts who were shedding S Typhi were asymptomatic, whereas 7 reported recent fever.<bold>Conclusions: </bold>One in 5 children with typhoid fever shed S Typhi, with shedding persisting even after antibiotics. One in 5 households had at least 1 contact of the child shedding S Typhi, highlighting potential concurrent typhoid infections in households in settings with poor water and sanitation. [ABSTRACT FROM AUTHOR]
- Subjects :
- TYPHOID fever
SALMONELLA typhi
HOUSEHOLDS
POLYMERASE chain reaction
Subjects
Details
- Language :
- English
- ISSN :
- 00221899
- Volume :
- 224
- Database :
- Complementary Index
- Journal :
- Journal of Infectious Diseases
- Publication Type :
- Academic Journal
- Accession number :
- 153891825
- Full Text :
- https://doi.org/10.1093/infdis/jiab409