Study on the mechanism of Renshen Gansong herb in the treatment of paroxysmal atrial fibrillation based on network pharmacology.

Objective: To explore the target gene and mechanism of effective components of Renshen- Gansong in the treatment of paroxysmal atrial fibrillation based on network pharmacology. Methods: The chemical constituents of Renshen-Gansong drug pairs were searched by TCMSP traditional Chinese medicine database. The potentially effective components were screened under the conditions of bioavailability (OB) = 30% and drug-like (DL) = 0.18, and the potential targets were predicted by TCMSP database. The human gene name corresponding to the potential target was found by Uniprot database, and the disease target of paroxysmal atrial fibrillation was searched by Genecards database, the intersection target was mapped with the potential target of drug pair, the Wayne diagram was drawn, and the disease-drugcomponent- target network map was constructed by Cytoscape3.7.2.The PPI protein interaction network map was constructed by STRING database to select the core targets, and finally GO analysis and KEGG analysis were carried out. Results: A total of 28 active components and 45 effective targets were obtained.GO enrichment analysis showed that the main pathways were neurotransmitter receptor activity, ion gated channel activity, passive transmembrane transporter activity, G protein coupled neurotransmitter receptor activity and so on. KEGG pathway enrichment analysis showed that the main pathways were IL-17 signal pathway, calcium signal pathway, TNF signal pathway and so on. Conclusion: Renshen-Gansong has a synergistic effect on the treatment of paroxysmal atrial fibrillation through multi-targets, multi-pathways and multiple signal pathways, which provides a basis for further study of drug mechanism and clinical guidance. [ABSTRACT FROM AUTHOR]