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Uvarmicranones A and B, two new benzoquinones and cytotoxic constituents from the stems of Uvaria micrantha (A. DC.) Hook. f. & Thomson.
- Source :
- Natural Product Research; Dec 2021, Vol. 35 Issue 24, p5643-5652, 10p
- Publication Year :
- 2021
-
Abstract
- Two novel benzoquinones, uvarmicranones A (1) and B (2), along with 15 known compounds (3 − 17) were isolated from the stems of Uvaria micrantha (Annonaceae). Their structures were elucidated by analyses of NMR and high-resolution mass data. A plausible biosynthetic pathway of uvarmicranone A (1) via Diels-Alder cycloaddition reaction was also proposed. Some isolated compounds were evaluated for their cytotoxic activities. Compounds 1, 14, and 15 showed moderate cytotoxic effects against T-cell acute lymphoblastic cells (MOLT-3), with IC<subscript>50</subscript> values of 7.83 ± 0.83, 6.53 ± 1.01, and 4.20 ± 0.29 μM, respectively. Additionally, compound 15 exhibited moderate cytotoxicity against cervical carcinoma cells (HeLa) with an IC<subscript>50</subscript> value of 7.00 ± 3.15 μM. [ABSTRACT FROM AUTHOR]
- Subjects :
- BENZOQUINONES
DIELS-Alder reaction
RING formation (Chemistry)
T cells
ANNONACEAE
Subjects
Details
- Language :
- English
- ISSN :
- 14786419
- Volume :
- 35
- Issue :
- 24
- Database :
- Complementary Index
- Journal :
- Natural Product Research
- Publication Type :
- Academic Journal
- Accession number :
- 153986195
- Full Text :
- https://doi.org/10.1080/14786419.2020.1824221