Contact allergy to topical diclofenac with systemic tolerance.

We report two patients with contact allergy to diclofenac and subsequent tolerance in oral challenge tests. Allergic contact dermatitis (ACD) after topically applied diclofenac1,2 and type IV reactions after oral intake are rarely reported.3 To date, no study exists on possible oral tolerance in patients with contact allergy to topical diclofenac. Keywords: allergic contact dermatitis; case report; diclofenac; systemic tolerance EN allergic contact dermatitis case report diclofenac systemic tolerance 41 43 3 12/17/21 20220101 NES 220101 Diclofenac (CAS 15307-86-5) is a widely used non-steroidal anti-inflammatory drug (NSAID). [Extracted from the article]