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Combination antiretroviral therapy is associated with reduction in liver fibrosis scores in patients with HIV and HBV co-infection.
- Source :
- AIDS Research & Therapy; 12/19/2021, Vol. 18 Issue 1, p1-9, 9p
- Publication Year :
- 2021
-
Abstract
- Background: Liver fibrosis is common in individuals with HIV/HBV co-infection, but whether cART could reverses liver fibrosis is unclear. Methods: This was a retrospective observational study. Binary logistic regression was used to assess predictors of liver fibrosis in individuals with HIV/HBV co-infection. Comparison of FIB-4 scores before and after cART were compared using X<superscript>2</superscript> test and t test. Results: Four hundred and fifty-eight individuals with HIV/HBV co-infection were included in this study. It was found that cART (HR 0.016, 95% CI: 0.009–0.136; P < 0.001) was one of protection factors to against liver fibrosis. Forty individuals who had normal levels of ALT, AST and PLT during the whole course of diseases were stratified into FIB-4 < 1.45 (n = 14), 1.45 ≤ FIB-4 ≤ 3.25 (n = 19) and FIB-4 > 3.25 (n = 7) groups by their FIB-4 scores before cART. In 1.45 ≤ FIB-4 ≤ 3.25 group, 57.9%(11/19) of the individuals dropped to FIB-4 < 1.45 group by cART; in FIB-4 > 3.25 group, 85.7%(6/79) dropped to 1.45 ≤ FIB-4 ≤ 3.25 group, while 14.3%(1/7) dropped to FIB-4 < 1.45 group. In cART-naive group, 1 year, 2–5 years and 5–10 years post-cART groups, FIB-4 scores were 4.29 ± 0.43, 3.63 ± 0.38, 2.90 ± 0.36 and 2.52 ± 0.38, respectively (P = 0.034); and the incidence of liver fibrosis were 7.38%(104/141), 63.6%(98/154), 60.8%(62/102) and 47.5%(29/61), respectively (P = 0.004). Conclusion: cART was associated with decreased FIB-4 scores and the benefit of cART in reversing liver fibrosis can sustain for a decade in patients with HIV/HBV co-infection. [ABSTRACT FROM AUTHOR]
- Subjects :
- HIV infections
HEPATITIS B
LIVER function tests
HIV-positive persons
COMBINATION drug therapy
SCIENTIFIC observation
CONFIDENCE intervals
ANTIRETROVIRAL agents
CIRRHOSIS of the liver
RETROSPECTIVE studies
PRE-tests & post-tests
COMPARATIVE studies
T-test (Statistics)
TREATMENT effectiveness
MIXED infections
CHI-squared test
DESCRIPTIVE statistics
LOGISTIC regression analysis
EVALUATION
Subjects
Details
- Language :
- English
- ISSN :
- 17426405
- Volume :
- 18
- Issue :
- 1
- Database :
- Complementary Index
- Journal :
- AIDS Research & Therapy
- Publication Type :
- Academic Journal
- Accession number :
- 154195857
- Full Text :
- https://doi.org/10.1186/s12981-021-00419-y