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Exosomes as Powerful Engines in Cancer: Isolation, Characterization and Detection Techniques.
- Source :
- Biosensors (2079-6374); Dec2021, Vol. 11 Issue 12, p518-518, 1p
- Publication Year :
- 2021
-
Abstract
- Exosomes, powerful extracellular nanovesicles released from almost all types of living cells, are considered the communication engines (messengers) that control and reprogram physiological pathways inside target cells within a community or between different communities. The cell-like structure of these extracellular vesicles provides a protective environment for their proteins and DNA/RNA cargos, which serve as biomarkers for many malicious diseases, including infectious diseases and cancers. Cancer-derived exosomes control cancer metastasis, prognosis, and development. In addition to the unique structure of exosomes, their nanometer size and tendency of interacting with cells makes them a viable novel drug delivery solution. In recent years, numerous research efforts have been made to quantify and characterize disease-derived exosomes for diagnosis, monitoring, and therapeutic purposes. This review aims to (1) relate exosome biomarkers to their origins, (2) focus on current isolation and detection methods, (3) discuss and evaluate the proposed technologies deriving from exosome research for cancer treatment, and (4) form a conclusion about the prospects of the current exosome research. [ABSTRACT FROM AUTHOR]
- Subjects :
- EXOSOMES
EXTRACELLULAR vesicles
METASTASIS
ENGINES
COMMUNICABLE diseases
Subjects
Details
- Language :
- English
- ISSN :
- 20796374
- Volume :
- 11
- Issue :
- 12
- Database :
- Complementary Index
- Journal :
- Biosensors (2079-6374)
- Publication Type :
- Academic Journal
- Accession number :
- 154344827
- Full Text :
- https://doi.org/10.3390/bios11120518