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Development of Green Methods for the Determination of Elemental Impurities in Commercial Pharmaceutical Tablets.
- Source :
- Sustainability (2071-1050); Jan2022, Vol. 14 Issue 1, p422-422, 1p
- Publication Year :
- 2022
-
Abstract
- In this study, two methods based on the use of diluted acids were developed: microwave-assisted wet digestion (MAWD) and microwave-assisted ultraviolet digestion (MAWD-UV). These methods are evaluated for the digestion of oral pharmaceutical drugs and further determination of elemental impurities from classes 1 (As, Cd, Hg and Pb) and 2A (Co, Ni and V) by inductively coupled plasma optical emission spectrometry (ICP-OES). Commercial drugs for the treatment of type 2 diabetes are used. No prior comminution is performed. For MAWD, the optimized conditions were 2 mol L<superscript>−1</superscript> or 3 mol L<superscript>−1</superscript> HNO<subscript>3</subscript>, 1 mL of 50% H<subscript>2</subscript>O<subscript>2</subscript> and a 45 min or 55 min irradiation program. For MAWD-UV, the condition using 1 mol L<superscript>−1</superscript> HNO<subscript>3</subscript>, 1.6 mL of 50% H<subscript>2</subscript>O<subscript>2</subscript> and a 55 min irradiation program enabled the digestion of all samples. In this way, efficient methods are proposed for the digestion of commercial pharmaceutical tablets for further determination of class 1 and 2A elemental impurities (ICH Q3D guidelines). [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 20711050
- Volume :
- 14
- Issue :
- 1
- Database :
- Complementary Index
- Journal :
- Sustainability (2071-1050)
- Publication Type :
- Academic Journal
- Accession number :
- 154616001
- Full Text :
- https://doi.org/10.3390/su14010422