Influence of glycaemic control on macular thickness in diabetic retinopathy.

Introduction: Diabetic macular oedema (DME) is one of the major cause of decreased visual acuity in patients with diabetic retinopathy. Poor glycaemic control is associated with increased incidence of DME. Methods: A total of 112 eyes of 112 patients were studied in this cross‐sectional study and were classified into three groups based on HbA1c: group 1 included patients with good glycaemic control (HbA1c ≤7%), group 2 included patients with moderate glycaemic control (HbA1c between 7% and 9%) and group 3 included patients with poor glycaemic control (HbA1c ≥9%). Results: We included 112 eyes of 112 patients. The mean duration of diabetes mellitus (DM) was 11.37 years. In statistical analysis, CMT (mean 188.80 ± 27.64 μm) positively correlated with mean HbA1c level (7.95 ± 1.29%) (r = 0.238, p <.05). There was a significant difference in CMT values among the three groups of HbA1c (F (2,109) = 19.39, p <.001). Post hoc analysis showed statistical significance between HbA1c≤7% and HbA1c ≥9% group and HbA1c 7%–9% and ≥9% group. However, statistical significance was not found among HbA1c ≤7% group and HbA1c 7%–9% group. Multiple regression analyses showed a significant correlation between CMT and HbA1c after adjusting for age and duration of diabetes. Conclusion: Serum HbA1c level has a significant correlation with CMT in diabetic patients. [ABSTRACT FROM AUTHOR]