ESTROGEN LEVELS IN BREAST CANCER WOMEN IN PRE AND POSTMENOPAUSAL PERIODS.

The present study was conducted on 75 women with breast cancer and 20 women as control in Baghdad teaching hospital for tumors at medicine city. Breast cancer women were treated by Adriamycin (Doxorubicin), sold under the brand name Adriamycin among others, is a chemotherapy medication used to treat cancer. This includes breast cancer, bladder cancer, Kaposi’s sarcoma, lymphoma, and acute lymphocytic leukemia. It is often used together with other chemotherapy agents. Doxorubicin is given by injection into a vein. Their ages ranged (38.06 ±3.01) years among the control group and (50.88 ±2.85) for before treatment (31.09 ±0.95) and treated with Doxorubicin (28.26 ±1.19) groups. The BMI (kg/m2) shows a nonsignificant increase (P £ 0.05) in before (31.09 ±0.95) in comparison with the control group (29.10 ±0.70). While before group shows a significant increase (31.09 ±0.95) when compared with the treated group (28.26 ±1.19). In the premenopausal cancer breast women, the levels of estrogen pg/ml were non-significant in before treated breast cancer group (68.84 ± 22.37) and (37.76 ± 6.97) in the treated breast cancer group in comparison with the control group (65.07 ± 26.25 ). In post-menopausal, the values decreased in before and treated cancer groups (12.07 ± 2.71; 22.28 ± 2.51) respectively in comparison with the control group (59.67 ± 31.46). The values were non-significant in before and treated groups. The estrogen levels were decreased significantly (P £ 0.01) in the post-menopausal (12.07 ± 2.71) group in comparison with before the pre-menopausal ( 68.84 ± 22.37) group. Also the levels were decreased significantly (P £ 0.01) in post-menopausal group (22.28±2.51) in comparison with treated pre -menopausal groups (37.76 ± 6.97). The pre and post-menopausal control groups showed non-significant difference (65.07 ± 26.25; 59.67 ± 31.46), respectively. The premenopausal of breast cancer in our study were 16/75 (21.33%) and 59/75 (78.66%) were menopausal. [ABSTRACT FROM AUTHOR]