Back to Search
Start Over
Synthesis and biological properties of novel structural analogs of isothiobarbamine.
- Source :
- Russian Chemical Bulletin; Nov2021, Vol. 70 Issue 11, p2220-2226, 7p
- Publication Year :
- 2021
-
Abstract
- Novel structural analogs of isothiobarbamine, which differ from the prototype scaffold by the substituent at position 2 of the pyrimidine heterocycle, were for the first time synthesized and characterized. Data acquired in pharmacological experiments in vivo revealed that compounds 1b—d and 10 increase physical productivity, whereas compounds 1c and 10 exhibit a nootropic effect, compound 8a shows a psychostimulating effect, and compound 1b exhibits anxiolytic properties. The results reported herein indicate that the drug discovery based on new structural analogs of isothiobarbamine is promising since it may lead to drugs for the prevention and treatment of asthenia (chronic fatigue syndrome). [ABSTRACT FROM AUTHOR]
- Subjects :
- BIOSYNTHESIS
CHRONIC fatigue syndrome
PYRIMIDINES
Subjects
Details
- Language :
- English
- ISSN :
- 10665285
- Volume :
- 70
- Issue :
- 11
- Database :
- Complementary Index
- Journal :
- Russian Chemical Bulletin
- Publication Type :
- Academic Journal
- Accession number :
- 154706019
- Full Text :
- https://doi.org/10.1007/s11172-021-3336-7