Back to Search
Start Over
Apolipoprotein E Genotype Contributes to Motor Progression in Parkinson's Disease.
- Source :
- Movement Disorders; Jan2022, Vol. 37 Issue 1, p196-200, 5p
- Publication Year :
- 2022
-
Abstract
- Background: Emerging evidence indicates that the apolipoprotein E (APOE) ε4 exacerbates α‐synuclein pathology. Objective: To determine whether APOE ε4 contributes to motor progression in early Parkinson's disease (PD). Methods: Longitudinal data were obtained from 384 patients with PD divided into APOE ε4 carriers (n = 85) and noncarriers (n = 299) in the Parkinson's Progression Marker Initiative. Participants underwent yearly motor assessments over a mean follow‐up period of 78.9 months. Repeated measures and linear mixed models were used to test the effects of APOE ε4. Results: The motor progression was significantly more rapid in patients with PD carrying APOE ε4 than in noncarriers (β = 0.283, P = 0.026, 95% confidence interval: 0.033–0.532). Through subgroup analysis, we found that the effect of APOE ε4 was significant only in patients with high amyloid β burden (β = 0.761, P < 0.001, 95% confidence interval: 0.0356–1.167). Conclusions: APOE ε4 may be associated with rapid motor progression in PD. © 2021 International Parkinson and Movement Disorder Society [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 08853185
- Volume :
- 37
- Issue :
- 1
- Database :
- Complementary Index
- Journal :
- Movement Disorders
- Publication Type :
- Academic Journal
- Accession number :
- 154758757
- Full Text :
- https://doi.org/10.1002/mds.28805