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T and NK Cell-Based Immunotherapy in Chronic Viral Hepatitis and Hepatocellular Carcinoma.
- Source :
- Cells (2073-4409); Feb2022, Vol. 11 Issue 2, p180-180, 1p
- Publication Year :
- 2022
-
Abstract
- A different approach for T cell-based immunotherapy is illustrated in the commentary by Hafezi et al., where adoptive cell therapy with autologous engineered T cells is considered in case of HBV-related HCC recurrence following liver transplantation. As these patients undergo immunosuppressive treatments that can compromise T cell reactivity, a new class of HBV-specific TCR-redirected T cells can be made temporarily resistant to immunosuppression, thanks to mutations in drug-specific target proteins, thus opening up new ways not only in case of HCC liver transplantation, but also for patients with other pathologies that need immunosuppressant therapies [[9]]. In chronic viral hepatitis and in hepatocarcinoma (HCC), antigen-specific T cells are deeply exhausted, and evidence of dysfunction has also been observed for NK cells, which can play a pathogenetic role, exerting a regulatory activity on adaptive immune responses. [Extracted from the article]
Details
- Language :
- English
- ISSN :
- 20734409
- Volume :
- 11
- Issue :
- 2
- Database :
- Complementary Index
- Journal :
- Cells (2073-4409)
- Publication Type :
- Academic Journal
- Accession number :
- 154803844
- Full Text :
- https://doi.org/10.3390/cells11020180