Response to Comment on Meek et al. Reappearance of C-Peptide During the Third Trimester in Type 1 Diabetes Pregnancy: Pancreatic Regeneration or Fetal Hyperinsulinism? Diabetes Care 2021;44:1826-1834.

The article presents the discussion on Ivanisevic and Djelmis publishing descriptions of the cohort of pregnant women with type 1 diabetes (T1D) (2). Topics include suboptimal glycemia and higher cord C-peptide, consistent with fetal hyperinsulinemia, and striking rates of neonatal morbidity; and fetal C-peptide crossing the placenta into maternal circulation in late pregnancy.