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Comparison of the tumor microenvironments of squamous cell carcinoma at different anatomical locations within the upper aerodigestive tract in relation to response to ICI therapy.

Authors :
van Duijvenvoorde, Maurice
Derks, Sarah
Bahce, Idris
Leemans, C René
van de Ven, Rieneke
Fransen, Marieke F
Source :
Clinical & Translational Immunology; 2022, Vol. 11 Issue 1, p1-15, 15p
Publication Year :
2022

Abstract

Immunotherapy with immune checkpoint inhibitors (ICI) has improved treatment outcomes in many cancer types and has focused attention on cancer immunity and the role of the tumor microenvironment (TME). Studies into efficacy of immunotherapy and TME are generally restricted to tumors in one anatomical location, while the histological type may have substantial influence on the contexture of the TME, perhaps more so than anatomical location, and subsequently to the response to immunotherapy. This review aims to focus on the TME in ICI‐treated tumors of the same histological type, namely carcinogen‐induced squamous cell carcinoma developing within the aerodigestive tract, at three locations, i.e. head and neck (HNSCC), esophagus (ESCC) and lung (LUSC). [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
20500068
Volume :
11
Issue :
1
Database :
Complementary Index
Journal :
Clinical & Translational Immunology
Publication Type :
Academic Journal
Accession number :
154886151
Full Text :
https://doi.org/10.1002/cti2.1363