Back to Search
Start Over
Plasma Levels of the Cytokines B Cell-Activating Factor (BAFF) and A Proliferation-Inducing Ligand (APRIL) in Schizophrenia, Bipolar, and Major Depressive Disorder: A Cross Sectional, Multisite Study.
- Source :
- Schizophrenia Bulletin; Jan2022, Vol. 48 Issue 1, p37-46, 10p
- Publication Year :
- 2022
-
Abstract
- Background Immune dysfunction has been implicated in the pathogenesis of schizophrenia and other nonaffective psychosis (SCZ), bipolar spectrum disorder (BIP) and major depressive disorder (MDD). The cytokines B cell-activating factor (BAFF) and A proliferation-inducing ligand (APRIL) belong to the tumor necrosis factor (TNF) super family and are essential in orchestrating immune responses. Abnormal levels of BAFF and APRIL have been found in autoimmune diseases with CNS affection. Methods We investigated if plasma levels of BAFF and APRIL differed between patients with SCZ, BIP, and MDD with psychotic symptoms (n = 2009) and healthy control subjects (HC, n = 1212), and tested for associations with psychotic symptom load, controlling for sociodemographic status, antipsychotic and other psychotropic medication, smoking, body-mass-index, and high sensitivity CRP. Results Plasma APRIL level was significantly lower across all patient groups compared to HC (P <.001; Cohen's d = 0.33), and in SCZ compared to HC (P <.001; d = 0.28) and in BIP compared to HC (P <.001; d = 0.37). Lower plasma APRIL was associated with higher psychotic symptom load with nominal significance (P =.017), but not with any other clinical characteristics. Plasma BAFF was not significantly different across patient groups vs HC, but significantly higher in BIP compared to HC (P =.040; d = 0.12) and SCZ (P =.027; d = 0.10). Conclusions These results show aberrant levels of BAFF and APRIL and association with psychotic symptoms in patients with SCZ and BIP. This suggest that dysregulation of the TNF system, mediated by BAFF and APRIL, is involved in the pathophysiology of psychotic disorders. [ABSTRACT FROM AUTHOR]
- Subjects :
- BIOMARKERS
RESEARCH
C-reactive protein
STATISTICS
NEUROLOGICAL disorders
PSYCHIATRIC drugs
CONFIDENCE intervals
ACQUISITION of data methodology
SCHIZOPHRENIA
CROSS-sectional method
BLOOD plasma
MEDICAL cooperation
CASE-control method
AUTOIMMUNE diseases
BLOOD collection
TUMOR necrosis factors
MENTAL depression
DESCRIPTIVE statistics
ANALYSIS of covariance
MEDICAL records
DATA analysis software
STATISTICAL correlation
DATA analysis
BIPOLAR disorder
Subjects
Details
- Language :
- English
- ISSN :
- 05867614
- Volume :
- 48
- Issue :
- 1
- Database :
- Complementary Index
- Journal :
- Schizophrenia Bulletin
- Publication Type :
- Academic Journal
- Accession number :
- 154897078
- Full Text :
- https://doi.org/10.1093/schbul/sbab106