Genome‐wide association meta‐analyses identify novel genetic risk loci and polygenic phenotype associations for heroin, methamphetamine and alcohol dependences.

Genetic correlation analysis using LD score regression3 showed MD and HD were significantly correlated ( I r SB g sb i = 0.8618, I p i = 7.361e-5), but not for HD and AD, MD and AD. This work presented a significant correlation between heroin and methamphetamine dependence (HD and MD) which distinguished with alcohol dependence (AD) at the genome-wide level. Genome-wide association meta-analyses identify novel genetic risk loci and polygenic phenotype associations for heroin, methamphetamine and alcohol dependences. [Extracted from the article]