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Asymmetric Synthesis of Fused Tetrahydroquinolines via Intra-molecular Aza-Diels–Alder Reaction of ortho -Quinone Methide Imines.

Authors :
Hofmann, Fabian
Gärtner, Cornelius
Kretzschmar, Martin
Schneider, Christoph
Source :
Synthesis; Feb2022, Vol. 54 Issue 4, p1055-1080, 26p
Publication Year :
2022

Abstract

Aza-Diels–Alder reactions are straightforward processes for the construction of N -heterocycles, featuring inherent atom-economy and stereospecificity. Intramolecular strategies allow the formation of bicyclic core structures with up to three stereocenters within a single step. Herein, this concept is combined with the chemistry of chiral Brønsted acid bound ortho -quinone methide imines to generate a range of interesting fused tetrahydroquinolines in a diastereo- and enantioselective- manner. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
00397881
Volume :
54
Issue :
4
Database :
Complementary Index
Journal :
Synthesis
Publication Type :
Academic Journal
Accession number :
154973032
Full Text :
https://doi.org/10.1055/a-1517-7515