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In-situ TiO2-x decoration of titanium carbide MXene for photo/sono-responsive antitumor theranostics.
- Source :
- Journal of Nanobiotechnology; 1/28/2022, Vol. 20 Issue 1, p1-14, 14p
- Publication Year :
- 2022
-
Abstract
- Background: Sonodynamic therapy (SDT) has emerged as a noninvasive therapeutic modality that involves sonosensitizers and low-intensity ultrasound. However, owing to the rapid recombination of charge carriers, most of the sonosensitizers triggered poor reactive oxygen species (ROS) generation, resulting in unsatisfactory sonodynamic therapeutic effects. Results: Herein, a photo/sono-responsive nanoplatform was developed through the in-situ systhesis of TiO<subscript>2-x</subscript> on the surface of two-dimensional MXene (titanium carbide, Ti<subscript>3</subscript>C<subscript>2</subscript>) for photoacoustic/photothermal bimodal imaging-guided near-infrared II (NIR-II) photothermal enhanced SDT of tumor. Because of several oxygen vacancies and smaller size (~ 10 nm), the in-situ formed TiO<subscript>2-x</subscript> nanoparticles possessed narrow band gap (2.65 eV) and high surface area, and thus served as a charge trap to restrict charge recombination under ultrasound (US) activation, resulting in enhanced sonodynamic ROS generation. Moreover, Ti<subscript>3</subscript>C<subscript>2</subscript> nanosheets induced extensive localized hyperthermia relieves tumor hypoxia by accelerating intratumoral blood flow and tumor oxygenation, and thus further strengthened the efficacy of SDT. Upon US/NIR-II laser dual-stimuli, Ti<subscript>3</subscript>C<subscript>2</subscript>@TiO<subscript>2-x</subscript> nanoplatform triggered substantial cellular killing in vitro and complete tumor eradication in vivo, without any tumor recurrence and systemic toxicity. Conclusion: Our work presents the promising design of photo/sono-responsive nanoplatform for cancer nanotheranostics. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 14773155
- Volume :
- 20
- Issue :
- 1
- Database :
- Complementary Index
- Journal :
- Journal of Nanobiotechnology
- Publication Type :
- Academic Journal
- Accession number :
- 154979420
- Full Text :
- https://doi.org/10.1186/s12951-022-01253-8