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Involvement of miR-214-3p/FOXM1 Axis During the Progression of Psoriasis.
- Source :
- Inflammation; Feb2022, Vol. 45 Issue 1, p267-278, 12p
- Publication Year :
- 2022
-
Abstract
- Psoriasis is a common, chronic, and relapsing skin disease characterized by hyperproliferation of keratinocytes and apoptosis delay. However, the molecular mechanisms underlying the progression of psoriasis remain elusive. MicroRNAs (miRNAs) are single-stranded, small non-coding RNAs that play a crucial role in the development of psoriasis by promoting targeted mRNA degradation or translational inhibition. Here, we report that miR-214-3p, one of the downregulated miRNAs identified in the skin of psoriatic patients and imiquimod (IMQ)-induced mouse models, can negatively regulate the expression of forkhead box M1 (FOXM1). miR-214-3p inhibition leads to hyperproliferation and increased apoptosis of keratinocytes in vitro. Moreover, we show that miR-214-3p inhibition causes an arrest of the cell cycle at the S stage by elevating the expression of NEK2, KIF20A, CENP-A, CENP-F, and Cyclin B1 and by reducing the expression of Cyclin D1 in HaCaT cells. In vivo, the administration of miR-214-3p attenuates the psoriasis-like phenotype in IMQ-induced mice. Collectively, our results suggest that miR-214-3p/FOXM1 axis in keratinocytes could be a novel target in the treatment of psoriasis. [ABSTRACT FROM AUTHOR]
- Subjects :
- PSORIASIS
NON-coding RNA
CELL cycle
SKIN diseases
DISEASE relapse
Subjects
Details
- Language :
- English
- ISSN :
- 03603997
- Volume :
- 45
- Issue :
- 1
- Database :
- Complementary Index
- Journal :
- Inflammation
- Publication Type :
- Academic Journal
- Accession number :
- 154980141
- Full Text :
- https://doi.org/10.1007/s10753-021-01544-6