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Bioactive polypeptide improves neuroinflammation by regulating microglia polarization.
- Source :
- Journal of Cellular & Molecular Medicine; Feb2022, Vol. 26 Issue 3, p945-949, 5p
- Publication Year :
- 2022
-
Abstract
- M1 microglia predominated in AD mice, which promoted the inflammatory cytokine expressions significantly. The microglia can clear A through phagocytosis and release pro-inflammatory cytokines and cytotoxic substances.4 In AD, microglia polarize to pro-inflammatory M1 phenotype upon stimulation. Nevertheless, RBAP can significantly reduce the proportion of M1 cells and inhibit the inflammatory cytokine expressions in M1 cells. [Extracted from the article]
Details
- Language :
- English
- ISSN :
- 15821838
- Volume :
- 26
- Issue :
- 3
- Database :
- Complementary Index
- Journal :
- Journal of Cellular & Molecular Medicine
- Publication Type :
- Academic Journal
- Accession number :
- 155058467
- Full Text :
- https://doi.org/10.1111/jcmm.17059