Bioactive polypeptide improves neuroinflammation by regulating microglia polarization.

M1 microglia predominated in AD mice, which promoted the inflammatory cytokine expressions significantly. The microglia can clear A through phagocytosis and release pro-inflammatory cytokines and cytotoxic substances.4 In AD, microglia polarize to pro-inflammatory M1 phenotype upon stimulation. Nevertheless, RBAP can significantly reduce the proportion of M1 cells and inhibit the inflammatory cytokine expressions in M1 cells. [Extracted from the article]