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Oxygen Metabolism-induced Stress Response Underlies Heart–brain Interaction Governing Human Consciousness-breaking and Attention.
- Source :
- Neuroscience Bulletin; Feb2022, Vol. 38 Issue 2, p166-180, 15p
- Publication Year :
- 2022
-
Abstract
- Neuroscientists have emphasized visceral influences on consciousness and attention, but the potential neurophysiological pathways remain under exploration. Here, we found two neurophysiological pathways of heart-brain interaction based on the relationship between oxygen-transport by red blood cells (RBCs) and consciousness/attention. To this end, we collected a dataset based on the routine physical examination, the breaking continuous flash suppression (b-CFS) paradigm, and an attention network test (ANT) in 140 immigrants under the hypoxic Tibetan environment. We combined electroencephalography and multilevel mediation analysis to investigate the relationship between RBC properties and consciousness/attention. The results showed that RBC function, via two independent neurophysiological pathways, not only triggered interoceptive re-representations in the insula and awareness connected to orienting attention but also induced an immune response corresponding to consciousness and executive control. Importantly, consciousness played a fundamental role in executive function which might be associated with the level of perceived stress. These results indicated the important role of oxygen-transport in heart-brain interactions, in which the related stress response affected consciousness and executive control. The findings provide new insights into the neurophysiological schema of heart-brain interactions. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 16737067
- Volume :
- 38
- Issue :
- 2
- Database :
- Complementary Index
- Journal :
- Neuroscience Bulletin
- Publication Type :
- Academic Journal
- Accession number :
- 155105308
- Full Text :
- https://doi.org/10.1007/s12264-021-00761-1