Back to Search Start Over

Baseline Amide Proton Transfer Imaging at 3T Fails to Predict Early Response to Induction Chemotherapy in Nasopharyngeal Carcinoma.

Authors :
Liu, Zhou
Zou, Liyan
Yang, Qian
Qian, Long
Li, Tianran
Luo, Honghong
Che, Canwen
Lei, Yuanyuan
Chen, Peng
Qiu, Chunyan
Liu, Xin
Wu, Yin
Luo, Dehong
Source :
Frontiers in Oncology; 2/8/2022, Vol. 12, p1-11, 11p
Publication Year :
2022

Abstract

Background: Early identification of nasopharyngeal carcinoma (NPC) patients with high risk of failure to induction chemotherapy (IC) would facilitate prompt individualized treatment decisions and thus reduce toxicity and improve overall survival rate. This study aims to investigate the value of amide proton transfer (APT) imaging in predicting short-term response of NPC to IC and its potential correlation with well-established prognosis-related clinical characteristics. Methods and Materials: A total of 80 pathologically confirmed NPC patients receiving pre-treatment APT imaging at 3T were retrospectively enrolled. Using asymmetry analysis, APT maps were calculated with mean (APT<subscript>mean</subscript>), 90<superscript>th</superscript> percentile (APT<subscript>90</subscript>) of APT signals in manually segmented NPC measured. APT values were compared among groups with different histopathological subtypes, clinical stages (namely, T, M, N, and overall stages), EBV-related indices (EBV-DNA), or responses to induction chemotherapy, using Mann–Whitney U test or Kruskal–Wallis H test. Results: NPC showed significantly higher APT<subscript>mean</subscript> than normal nasopharyngeal tissues (1.81 ± 0.62% vs. 1.32 ± 0.56%, P < 0.001). APT signals showed no significant difference between undifferentiated and differentiated NPC subtypes groups, different EBV-DNA groups, or among T, N, M stages and overall clinical stages of II, III, IVA and IVB (all P > 0.05). Similarly, baseline APT-related parameters did not differ significantly among different treatment response groups after IC, no matter if evaluated with RECIST criteria or sum volumetric regression ratio (SVRR) (all P > 0.05). Conclusion: NPC showed significantly stronger APT effect than normal nasopharyngeal tissue, facilitating NPC lesion detection and early identification. However, stationary baseline APT values exhibited no significant correlation with histologic subtypes, clinical stages and EBV-related indices, and showed limited value to predict short-term treatment response to IC. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
2234943X
Volume :
12
Database :
Complementary Index
Journal :
Frontiers in Oncology
Publication Type :
Academic Journal
Accession number :
155125674
Full Text :
https://doi.org/10.3389/fonc.2022.822756