Leadless pacemaker implantation sites confirmed by computed tomography and their parameters and complication rates.

Background: Implantations of leadless pacemakers in the septum lower the risk of cardiac perforation. However, the relationship between the implantation site and the success rate, complication rate, and pacemaker parameters are not well‐investigated. Methods: Patients who underwent leadless pacemaker implantation with postprocedural computed tomography (CT) between September 2017 and November 2020 were analyzed. Septum was targeted with fluoroscopic guidance with contrast injection. We divided patients into two groups based on the implantation site confirmed by CT: septal and non‐septal, which included the anterior/posterior edge of the septum and free wall. We compared the complication rates and pacemaker parameters between the two groups. Results: A total of 67 patients underwent CT after the procedure; among them, 28 were included in the septal group and 39 were included in the non‐septal group. The non‐septal group had significantly higher R wave amplitudes (6.5 ± 3.3 vs. 9.7 ± 3.9 mV, p =.001), lower pacing threshold (1.0 ± 0.94 vs. 0.63 ± 0.45 V/0.24 ms, p =.02), and higher pacing impedance (615 ± 114.1 vs. 712.8 ± 181.3 ohms, p =.014) after the procedure compared to the septal group. Cardiac injuries were observed in four patients (one cardiac tamponade, one possible apical hematoma, two asymptomatic pericardial effusion), which were only observed in the non‐septal group. Conclusions: Leadless pacemaker implantation may be technically challenging with substantial number of patients with non‐septal implantation when assessed by CT. Septal implantation may have a lower risk of cardiac injury but may lead to inferior pacemaker parameters than non‐septal implantation. [ABSTRACT FROM AUTHOR]