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Resveratrol: Potential Application in Sepsis.

Authors :
Li, Jiajia
Zeng, Xiaoting
Yang, Fuxun
Wang, Lan
Luo, Xiaoxiu
Liu, Rongan
Zeng, Fan
Lu, Sen
Huang, Xiaobo
Lei, Yu
Lan, Yunping
Source :
Frontiers in Pharmacology; 2/9/2022, Vol. 12, p1-10, 10p
Publication Year :
2022

Abstract

Sepsis is a life-threatening organ dysfunction syndrome caused by host response disorders due to infection or infectious factors and is a common complication of patients with clinical trauma, burns, and infection. Resveratrol is a natural polyphenol compound that is a SIRT-1 activator with anti-inflammatory, antiviral, antibacterial, antifungal inhibitory abilities as well as cardiovascular and anti-tumor protective effects. In recent years, some scholars have applied resveratrol in animal models of sepsis and found that it has an organ protective effect and can improve the survival time and reduce the mortality of animals with sepsis. In this study, Medline (Pubmed), embase, and other databases were searched to retrieve literature published in 2021 using the keywords "resveratrol" and "sepsis," and then the potential of resveratrol for the treatment of sepsis was reviewed and prospected to provide some basis for future clinical research. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
16639812
Volume :
12
Database :
Complementary Index
Journal :
Frontiers in Pharmacology
Publication Type :
Academic Journal
Accession number :
155188015
Full Text :
https://doi.org/10.3389/fphar.2022.821358