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Limited spread of a rare spike E484K-harboring SARS-CoV-2 in Marseille, France.
- Source :
- Archives of Virology; Feb2022, Vol. 167 Issue 2, p583-589, 7p
- Publication Year :
- 2022
-
Abstract
- We detected SARS-CoV-2 of PANGO lineage R.1 with the spike substitution E484K in three patients. Eleven other sequences in France and 8,831 worldwide were available from GISAID, 92% originating from Japan. The three genome sequences from our institute were phylogenetically closest to another from Guinea-Conakry, where one of the patients had travelled. These viruses did not exhibit any unusual features in cell culture. Spike structural predictions indicated a 1.3-time higher transmissibility index than for the globally spread B.1.1.7 variant but also an affinity loss for gangliosides that might have slowed dissemination. The spread of new SARS-CoV-2 mutants/variants is still not well understood and therefore difficult to predict, and this hinders implementation of effective preventive measures, including adapted vaccines. [ABSTRACT FROM AUTHOR]
- Subjects :
- SARS-CoV-2
CELL culture
GANGLIOSIDES
Subjects
Details
- Language :
- English
- ISSN :
- 03048608
- Volume :
- 167
- Issue :
- 2
- Database :
- Complementary Index
- Journal :
- Archives of Virology
- Publication Type :
- Academic Journal
- Accession number :
- 155238618
- Full Text :
- https://doi.org/10.1007/s00705-021-05331-4