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Impact of Oral Metronidazole, Vancomycin, and Fidaxomicin on Host Shedding and Environmental Contamination With Clostridioides difficile.
- Source :
- Clinical Infectious Diseases; 2/15/2022, Vol. 74 Issue 4, p648-656, 9p
- Publication Year :
- 2022
-
Abstract
- Background Shedding of Clostridioides difficile spores from infected individuals contaminates the hospital environment and contributes to infection transmission. We assessed whether antibiotic selection affects C. difficile shedding and contamination of the hospital environment. Methods In this prospective, unblinded, randomized controlled trial of hospitalized adults with C. difficile infection, patients were randomized 1:1:1 to receive fidaxomicin, oral vancomycin, or metronidazole. The primary outcome was change in environmental contamination rate during treatment. Secondary outcomes included stool shedding, total burden of contamination, and molecular relatedness of stool versus environmental C. difficile isolates. Results Of 33 patients enrolled, 31 (94%) completed the study. Fidaxomicin (−0.36 log<subscript>10</subscript> colony-forming units [CFUs]/d [95% confidence interval (CI), −.52 to −.19]; P < .01) and vancomycin (−0.17 log<subscript>10</subscript> CFUs/d [−.34 to −.01]; P = .05) were associated with more rapid decline in C. difficile shedding than metronidazole (−0.01 log<subscript>10</subscript> CFUs/d [95% CI, −.10 to.08). Both vancomycin (6.3% [95% CI, 4.7–8.3) and fidaxomicin (13.1% [10.7–15.9]) were associated with lower rates of environmental contamination than metronidazole (21.4% [18.0–25.2]). With specific modeling of within-subject change over time, fidaxomicin (adjusted odds ratio, 0.83 [95% CI,.70–.99]; P = .04) was associated with more rapid decline in environmental contamination than vancomycin or metronidazole. Overall, 207 of 233 environmental C. difficile isolates (88.8%) matched patient stool isolates by ribotyping, without significant difference by treatment. Conclusions Fidaxomicin, and to a lesser extent vancomycin, reduces C. difficile shedding and contamination of the hospital environment relative to metronidazole. Treatment choice may play a role in reducing healthcare-associated C. difficile transmission. Clinical Trials Registration NCT02057198. [ABSTRACT FROM AUTHOR]
- Subjects :
- FECAL analysis
HEALTH facilities
CONFIDENCE intervals
BACTERIAL contamination
VANCOMYCIN
CLOSTRIDIOIDES difficile
CROSS infection
METRONIDAZOLE
RANDOMIZED controlled trials
DESCRIPTIVE statistics
BACTERIOPHAGE typing
FIDAXOMICIN
STATISTICAL sampling
ODDS ratio
LONGITUDINAL method
PHARMACODYNAMICS
Subjects
Details
- Language :
- English
- ISSN :
- 10584838
- Volume :
- 74
- Issue :
- 4
- Database :
- Complementary Index
- Journal :
- Clinical Infectious Diseases
- Publication Type :
- Academic Journal
- Accession number :
- 155492776
- Full Text :
- https://doi.org/10.1093/cid/ciab473